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Developing Nitric Oxide Releasing Polymers to Improve the In Vivo Biocompatibility and Performance of Implanted Sensors
Dr. Megan C. Frost
Assistant Professor, Department of Biomedical Engineering, Michigan Technological University
|01/25/2008 - 3:00 pm - Chem Sci Room 101|
Polymeric materials used to coat or construct biomedical devices universally inspire a foreign body response when in contact with a biological system (e.g., thrombus formation on the polymer surface when in contact with blood, inflammatory response in subcutaneous tissue, etc.). Nitric oxide (NO) has been shown to have a number of physiological functions, including serving as a potent inhibitor of platelet adhesion and activation and mediating the inflammatory response. An NO-releasing silicone rubber coating was used to fabricate intravascular amperometric oxygen sensors that were evaluated in porcine femoral and carotid arteries. The NO-releasing sensors showed greatly enhanced hemocompatibility and improve analytical performance. Future work will concentrate on the development of S-nitrosothiol NO-donors that can be incorporated into hydrophobic polymers which utilize light as an external on/off trigger to initiate NO release. These materials show completely reversible and controllable NO generation based on the duration and intensity of light irradiating the material, which will offer precise control of the level of NO delivered at the tissue/polymer interface.