Department of Chemistry

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Indole Based Antioxidants for the Treatment of Ischemia Reperfusion Injury


Mr. Andrew Chapp

Master's candidate, Department of Chemistry, Michigan Technological University
07/06/2012 - 10:00 am - Room 211, Chemical Sciences and Engg. Building

Abstract:


With the number of ischemia reperfusion (I/R) injuries on the rise, and a lack of pharmacological intervention aimed at reducing free radical damage associated with I/R, we have developed 30 indole phenolic antioxidants that were synthesized by click chemistry to couple our indole with a phenolic or anisole derivative. The total antioxidant activity of the analogues was tested in vitro using the ferric thiocyanate lipid emulsion method. Compounds containing hydroxyl or methoxy aromatics at the 3 or 4 position on the aromatic coupled to the indole exhibited increased antioxidant scavenging. 4-methoxyindole derivatives (8a-e) exhibited increased scavenging (p < 0.05) compared to the known antioxidant butylated hydroxyanisole (BHA).

Department of Chemistry

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Ph. 906-487-2048
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Email: chemistry@mtu.edu

Michigan Technological University

1400 Townsend Drive
Houghton, Michigan 49931-1295
906-487-1885

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